The article presents results of a study on the correlation of histomorphometric parameters of the heart in case of death from alcoholic cardiomyopathy (ACM), ischemic heart disease (IHD) and mechanical injury (control group) by the method of correlation analysis. The previous studies show that normally with age, the myocardium of the sinoatrial node (SAN) is most worn out and fibrosed. In case of IHD the His bundles are most worn out and fibrosed. In case of ACM, histomorphological changes are uniform in all areas of the myocardium. This indicator can be used in practice when providing differential diagnosis of the above-described types of pathology and causes of death. In addition, the results of our study confirm that myocardial lipomatosis is more typical of ACM, which increases its diagnostic value.