Multisystem inflammatory syndrome in children associated with new coronavirus infection (Covid-19): Clinical and morphological comparisons

Multisystem Inflammatory Syndrome in Children (MIS-C) associated with new coronavirus infection (COVID-19), with signs of Kawasaki disease (KD) and toxic shock syndrome, well-defined diagnostic criteria, is the most severe manifestation of COVID-19 in pediatric patients. MIS-C is analogous to the cytokine storm in children with COVID-19. The article presents a clinical observation of a child with MIS-C with a lethal outcome. Clinical and anamnestic data, the results of laboratory and instrumental research allowed to diagnose MIS-C in a 2-year-old girl with full KD form. Autopsy results, detailed microscopic examination, which revealed systemic vasculitis of small and medium-sized vessels, inflammatory infiltrates in different organs, are presented, clinical and morphological comparisons are made. © 2020, Pediatria Ltd.. All rights reserved.

Authors
Ovsyannikov D.Yu. 1, 2 , Novikova Y.Yu.1, 2 , Abramov D.S.3 , Angel A.E.2 , Glazyrina A.A. 1, 2 , Kantemirova M.G. 1, 2 , Kislyakov A.N.2 , Kryshova E.S.2 , Kurbanova S.Kh. 2 , Petryaykina E.E. 1, 2, 4 , Rtishchev A.Yu. 1, 2, 4 , Tigai Z.G. 1 , Kharkin A.V.2 , Shalatonin M.P. 2
Journal
Pediatriya - Zhurnal im G.N. Speranskogo
Number of issue
6
Language
Russian
Pages
119-126
Status
Published
Link
External link
DOI
10.24110/0031-403X-2020-99-6-119-126
Volume
99
Year
2020
Organizations
  • 1 Рeoples’ Friendship University of Russia, Moscow, Russian Federation
  • 2 Morozov Children’s City Clinical Hospital, Moscow, Russian Federation
  • 3 National Scientific-Practical Center of Pediatric Hematology, Oncology and Immunology n.a. D. Rogachev, Moscow, Russian Federation
  • 4 Pirogov Russian National Research Medical University, Moscow, Russian Federation
Keywords
Clinical observation; COVID-19; Kawasaki disease; Pathological anatomy; Pediatric multisystem inflammatory syndrome
Date of creation
20.04.2021
Date of change
20.04.2021
Short link
https://repository.rudn.ru/en/records/article/record/72577/
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CLINICAL, LABORATORY-INSTRUMENTAL CHARACTERISTICS, COURSE AND THERAPY OF PEDIATRIC MULTISYSTEM INFLAMMATORY SYNDROME ASSOCIATED WITH COVID-19

Article
Novikova Y.Y., Ovsyannikov D.Yu., Glazyrina A.A., Zhdanova O.I., Zvereva N.N., Karpenko M.A., Kryshova E.S., Kurbanova S.Kh., Rtishchev A.Yu., Sayfullin R.F., Kharkin A.V., Shchederkina I.O., Bryksina E.Yu., Bogdan P.I., Kolganova N.I., Sergeev D.A., Zorina M.A., Petryaykina E.E., Gorev V.V.
Pediatriya - Zhurnal im G.N. Speranskogo. Vol. 99. 2020. P. 73-83