The integrated approach to diagnosis and dispensary monitoring of women with high risk for breast cancer, the active detection of combined pathology of endometrium are promising directions in prevention and timely diagnosis of breast and uterus malignant neoplasms. The study established that particular correction of measures of secondary prevention of breast cancer is needed, including formation of risk group and organization of dynamic monitoring of women with high risk of breast cancer development. The comprehensive examination of reproductive system organs, including evaluation of risk factors, combined use of mammography and sonography methods to examine mammary glands and condition of endometrium, can to increase accuracy of differential diagnosis and to avoid unneeded invasive interventions with mammary glands and early diagnosis of endometrial pathology.