Synthesis and biological evaluation of novel phane-structured diazacrowns containing γ-piperidone and pyridine rings

Six novel phane-structured diazacrowns containing γ-piperidone and pyridine rings were synthesized from podand 2-+,6-bis(2-formylphenoxymethyl)pyridine, with the γ-piperidone moiety having been constructed in the course of its domino condensation with simple ketones and ammonium acetate. The compounds were tested in vitro for antimicrobial and cytotoxic activity against four human cancer cell lines (Hep-G2, RD, MCF-7, Lu-1) and the Vero cell line. X-Ray structure study of one representative compound revealed its rac-1RS,23SR,24RS,26SR configuration. © 2020

Authors
Nguyen L.M.1, 2 , Truong H.H. 3 , Khrustalev V.N. 3, 4 , Truong S.T.1 , Nguyen D.T. 1 , Tran V.T.T.1 , Mai S.T.1 , Tran V.T.1 , Le A.T. 1
Journal
Mendeleev Communications
Publisher
Royal Society of Chemistry
Number of issue
6
Language
English
Pages
753-755
Status
Published
Link
External link
DOI
10.1016/j.mencom.2020.11.021
Volume
30
Year
2020
Organizations
  • 1 Faculty of Chemistry, VNU University of Science, Vietnam National University, Hanoi, 100000, Viet Nam
  • 2 Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Thai Nguyen University of Medicine and Pharmacy, Thai Nguyen City, Viet Nam
  • 3 Faculty of Science, Peoples Friendship University of Russia (RUDN University), Moscow, 117198, Russian Federation
  • 4 N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, 119991, Russian Federation
Keywords
antimicrobial; cytotoxicity; diazacrownophane; domino condensation; pyridine; γ-piperidone
Date of creation
20.04.2021
Date of change
20.04.2021
Short link
https://repository.rudn.ru/en/records/article/record/72568/
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