Influence of Polymers on the Physicochemical Properties of Benzonal in Solid Dispersions

Abstract: The influence of solid dispersions (SDs) on some physicochemical properties of benzonal is studied. Investigated: benzonal and its SD with polyvinylpyrrolidone-10 000 (PVP), polyethylene glycol-1500 (PEG), β-cyclodextrin (CD). The preparation of SD by the solvent removal method increases the solubility and dissolution rate of benzonal in water. The solubility increases by 3.5–5.5 times; and the speed of dissolving, by 4.0–10.0 times. The complex of physical and chemical research methods suggests that the preparation of an SD with the studied polymers is accompanied by loss of crystallinity and formation of a solid solution of benzonal in the polymer, as well as solubilization and formation of colloidal solutions of benzonal during subsequent dissolution of SD in water. The results obtained can be used in the development of fast-dissolving benzonal tablets with increased release and bioavailability. © 2020, Allerton Press, Inc.

Authors
Krasnyuk I.I.Jr. , Beliatskaya A.V.1 , Krasnyuk I.I. 1 , Stepanova O.I. 1 , Kuzmenko A.N.1 , Lucenko S.V.1 , Kasimovskaya N.A.1 , Matyushin A.A.1 , Mazyarkin E.V.1 , Vorob’yov A.N. 2 , Nesterenko E.P.3
Journal
Moscow University Chemistry Bulletin
Publisher
Pleiades Publishing
Number of issue
6
Language
English
Pages
388-390
Status
Published
Link
External link
DOI
10.3103/S0027131420060127
Volume
75
Year
2020
Organizations
  • 1 Sechenov University, Moscow, 119991, Russian Federation
  • 2 RUDN University, Moscow, 117198, Russian Federation
  • 3 The National Centre for Sensor Research, Dublin City University, Dublin 9, Glasnevin, Ireland
Keywords
benzonal; polyethylene glycol (PEG); polyvinylpyrrolidone (PVP); solid dispersions; solubility; β‑cyclodextrin
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