Clozapine: Mechanisms of toxicity and side effects

Clozapine is an atypical antipsychotic agent with a confirmed effectiveness which is widely used in the clinical practice. However, its administration is associated with a high risk of serious adverse events. Life-threatening conditions related to administration of clozapine may be a result of idiosyncrasy, acute poisoning resulting from unintentional overdose of the prescribed dug, suicidal behavior, and criminal actions. The review presents current data on the mechanism of therapeutic and toxic effect of clozapine. It describes the effect of clozapine on cell receptors and ultracellular structures. It dwells on the contribution of major and intermediate metabolites of this medicinal agent to the development of toxic effects. © 2018, V.A. Negovsky Research Institute of General Reanimatology. All rights reserved.

Authors
Babkina A.S. 1, 2 , Golubev A.M. 1, 2 , Sundukov D.V. 2 , Bashirova A.R. 2 , Golubev M.A. 3
Journal
Obshchaya Reanimatologiya
Publisher
V.A. Negovsky Research Institute of General Reanimatology
Number of issue
2
Language
English
Pages
35-45
Status
Published
Link
External link
DOI
10.15360/1813-9779-2018-2-35-45
Volume
14
Year
2018
Organizations
  • 1 V. A. Negovsky Research Institute of General Reanimatology, Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, 25 Petrovka Str., Build. 2Moscow 107031, Russian Federation
  • 2 Peoples’ Friendship University of Russia, 6 Miklukho-Ma?laya Str., Moscow, Moscow 117198, Russian Federation
  • 3 Corporation «Medical electronic data», 4 Sretensky tupikMoscow 107045, Russian Federation
Keywords
Acute poisoning; Agranulocytosis; Cardiotoxicity; clozapine; Clozapine-induced myocarditis; Drug metabolism
Date of creation
19.10.2018
Date of change
03.03.2022
Short link
https://repository.rudn.ru/en/records/article/record/7249/
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