Total knee replacement is one of the most efficient surgical interventions providing the functional recovery of the extremity and removal of pain syndrome in patients suffering from degenerative and dystrophic changes of the knee joint. One of the rarest postsurgical complications is formation of arteriovenous fistula as result of an injury to branches of magistral vessels. Objective - to review the causes of formation of arteriovenous fistula by the example of a clinical case. Materials and methods. According to the literature data, the precise causes of arteriovenous fistula are unknown at the present time. We presented the analysis of the world literature relating to the problem of formation of arteriovenous fistula in patients after total knee joint replacement. Results. In our case, considering the anamnesis of the patient's disease (falling from the level of her own height) and absent data on intrasurgical or postsurgical complications within 9 months, one can suppose that the possible cause of formation of arteriovenous fistula between the branch of the popliteal artery and the popliteal vein is a traumatic impaction. Conclusion. Formation of arteriovenous fistula is a very rare complication after total knee joint replacement. During differential diagnosis one should consider the possibility of this complication. © 2019 The Charity Fund of Clinical Center of Miners' Health Protection. All rights reserved.