Rh(III)-Catalyzed C−H Activation/Annulation of Aryl Hydroxamates with CF3-Containing α-Propargyl α-Amino Acid Derivatives

A series of new orthogonally protected α-CF3-substituted α-amino carboxylates, and α-amino phosphonates decorated with pharmacophore isoquinolone core has been elaborated through the Rh(III)-catalyzed C−H activation/annulation of aryl hydroxamates with propargyl-containing α-amino acid derivatives and their phosphorus analogues. © 2021 Wiley-VCH GmbH

Authors
Vorobyeva D.V.1 , Petropavlovskikh D.A.1 , Godovikov I.A.1 , Nefedov S.E. 2 , Osipov S.N. 1, 3
Journal
European Journal of Organic Chemistry
Number of issue
12
Language
English
Pages
1883-1890
Status
Published
Link
External link
DOI
10.1002/ejoc.202100040
Volume
2021
Year
2021
Organizations
  • 1 Institute of Organoelement compounds, Russian Academy of Sciences, Vavilov str. 28, Moscow, 119991, Russian Federation
  • 2 Institute of General and Inorganic Chemistry, Russian Academy of Sciences, Leninsky pr. 31, Moscow, 119991, Russian Federation
  • 3 Peoples' Friendship University of Russia (RUDN University), Miklukho-Maklaya Str. 6, Moscow, 117198, Russian Federation
Keywords
Amino phosphonates; Catalysis; C−H activation; Fluorinated amino acids; Isoquinolones
Date of creation
20.04.2021
Date of change
20.04.2021
Short link
https://repository.rudn.ru/en/records/article/record/72016/
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