Patient-Specific Modelling of Blood Coagulation

Blood coagulation represents one of the most studied processes in biomedical modelling. However, clinical applications of this modelling remain limited because of the complexity of this process and because of large inter-patient variation of the concentrations of blood factors, kinetic constants and physiological conditions. Determination of some of these patients-specific parameters is experimentally possible, but it would be related to excessive time and material costs impossible in clinical practice. We propose in this work a methodological approach to patient-specific modelling of blood coagulation. It begins with conventional thrombin generation tests allowing the determination of parameters of a reduced kinetic model. Next, this model is used to study spatial distributions of blood factors and blood coagulation in flow, and to evaluate the results of medical treatment of blood coagulation disorders. © 2021, The Author(s), under exclusive licence to Society for Mathematical Biology.

Authors
Ratto N.1 , Bouchnita A.2 , Chelle P.3, 4 , Marion M.1 , Panteleev M.6, 7, 8 , Nechipurenko D.6, 7, 8 , Tardy-Poncet B.4, 5 , Volpert V. 9, 10, 11
Journal
Bulletin of Mathematical Biology
Publisher
Springer
Number of issue
5
Language
English
Status
Published
Link
External link
DOI
10.1007/s11538-021-00890-8
Number
50
Volume
83
Year
2021
Organizations
  • 1 UMR 5208 CNRS, Institute Camille Jordan, Ecole Centrale de Lyon, Ecully, France
  • 2 University of Texas at Austin, Austin, TX 78712, United States
  • 3 Center for Health Engineering, UMR 5307, Ecole Nationale Superieure des Mines de Saint-Etienne, Saint-Étienne, 2023, France
  • 4 EA3065, University Jean Monnet, Saint-Étienne, 42023, France
  • 5 Inserm CIC1408, CHU de Saint-Etienne, Saint-Étienne, 42023, France
  • 6 Faculty of Physics, Lomonosov Moscow State University, Moscow, Russian Federation
  • 7 Center for Theoretical Problems of Physicochemical Pharmacology of the Russian Academy of Sciences, Moscow, Russian Federation
  • 8 National Medical Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitry Rogachev, Moscow, Russian Federation
  • 9 UMR 5208 CNRS, Institut Camille Jordan, University Lyon 1, Villeurbanne, 69622, France
  • 10 INRIA Team Dracula, INRIA Lyon La Doua, Villeurbanne, 69603, France
  • 11 Peoples’ Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya St, Moscow, 117198, Russian Federation
Keywords
Blood coagulation; Blood flow; Reaction–diffusion waves; Thrombin generation curves; Treatment
Date of creation
20.04.2021
Date of change
20.04.2021
Short link
https://repository.rudn.ru/en/records/article/record/71977/
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