Colloquium Mathematicum.
Institute of Mathematics. Polish Academy of Sciences.
Vol. 153.
2018.
P. 97-101
Unexpected cyclization of 2-(2-aminophenyl)indoles with nitroalkenes to furnish indolo[3,2-: C] quinolines
The polyphosphoric acid-mediated reaction of 2-(2-aminophenyl)indenes with nitroalkenes was tested in the frame of synthetic studies towards CDK inhibitors with the paullone core. Unexpectedly, this reaction proceeded via a different mechanistic pathway affording derivatives of the natural alkaloid isocryptolepine. The scope of this unusual transformation was investigated and a mechanistic rationale explaining this outcome is offered. This journal is © The Royal Society of Chemistry.
Authors
Aksenov A.V.1
,
Aksenov D.A.1
,
Griaznov G.D.1,
2
,
Aksenov N.A.
1
,
Voskressensky L.G.
3
,
Rubin M.1,
2
Publisher
Royal Society of Chemistry
Number of issue
23
Language
English
Pages
4325-4332
Status
Published
Link
Volume
16
Year
2018
Organizations
- 1 Department of Chemistry, North Caucasus Federal University, 1a Pushkin St., Stavropol, 355009, Russian Federation
- 2 Department of Chemistry, University of Kansas, 1251 Wescoe Hall Dr, Lawrence, KS 66045-7582, United States
- 3 Department of Chemistry, Peoples' Friendship University of Russia, 6 Mikhluho-Maklaya St., Moscow, Russian Federation
Keywords
Positive ions; CDK inhibitors; Mechanistic pathways; Mediated reactions; Nitroalkenes; Polyphosphoric acids; Synthetic study; Chemistry
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Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics).
Vol. 10878 LNCS.
2018.
P. 695-702