Objective. To review published scientific papers in order to analyze an evidence base for a strategy for choosing therapy in women with abnormal uterine bleeding (AMC), obesity, and smoking. Material and methods. Foreign and Russian articles published in the past 7 years and selected in Pubmed were used. Results. The types of AMC were analyzed in relation to its etiological factors. Different methods for treating patients with uterine bleeding varying in severity were comparatively analyzed. Conclusion. It is appropriate to concomitantly use dydrogesterone and tranexamic acid in phase 2 of the menstrual cycle during 3-4 menstrual cycles in women who smoke and/or in those with obesity and AMC. © 2018, Bionika Media Ltd. All rights reserved.