Dynamics of Expression of Cytokine Genes and Macrophage Content in the Lungs and Kidneys after Subtotal Hepatectomy in Rats

The role of the lungs and kidneys in liver regeneration after subtotal hepatectomy was studied on a rat model. It was found that production of hepatocyte growth factor (HGF) in the lungs and kidneys and expression of cytokine genes Il1b, Il6, Il10, and tnfa significantly increased. Analysis of the dynamics of lung macrophage population showed that accumulation of HGF and the increase in the expression of cytokine genes in the lungs were accompanied by simultaneous increase in the number of CD68+ cells, which attested to the leading role of macrophages in activation of HGF synthesis in the lungs. Macrophage content in the kidneys after subtotal hepatectomy did not increase. © 2018, Springer Science+Business Media, LLC, part of Springer Nature.

Authors
El’chaninov A.V. 1, 4 , Fatkhudinov T.K. 1, 4 , Arutyunyan I.V. 1 , Makarov A.V.1, 3 , Usman N.Y.1 , Mikhailova L.P.2 , Lokhonina A.V.1 , Botchey V.M. 4 , Glinkina V.V.3 , Bol’shakova G.B.2
Journal
Bulletin of Experimental Biology and Medicine
Publisher
New York Consultants BureauSpringer / Автономная некоммерческая организация Издательство Российской академии медицинских наук
Number of issue
1
Language
English
Pages
136-141
Status
Published
Link
External link
DOI
10.1007/S10517-018-4115-9
Volume
165
Year
2018
Organizations
  • 1 V. I. Kulakov National Medical Research Center for Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation, Moscow, Russian Federation
  • 2 Research Institute of Human Morphology, Moscow, Russian Federation
  • 3 N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation, Moscow, Russian Federation
  • 4 Peoples’ Friendship University of Russia, Moscow, Russian Federation
Keywords
kidneys; liver; lungs; regeneration; subtotal resection
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