The paper is dedicated to the developing methods of evaluation of life-cycle resource provision for science-intensive products. This method estimates and explains why a particular volume of resources should be involved to execute science-intensive projects. The method of estimation and evaluation of resource costs that are needed for completion of a science-intensive project provides a glimpse of maximum resource costs required for completion of particular types of work, as well as planned organizational and technical activities that ensure rational and effective use of resources. It uses direct resource cost calculation methods and those based on information about analogs. the method allows for evaluation of an enterprise's resource capacity and offers a resource potential calculation pattern, which helps evaluate the amount of work that needs to be carried out to male science-intensive products and which an enterprise can manage with the help of its resource potential.