Electrochemical characterization of a novel nimesulide anti-inflammatory drug analog: LQFM-091

Nimesulide is an anti-inflammatory drug (NSAID) whose preferential selectivity for cyclooxygenase-2 (COX-2) leads to fewer adverse effects. Nimesulide acts on a single metabolic pathway of the arachidonic acid cascade. Recent studies show that multi-target NSAID is an important strategy for obtaining drugs fewer adverse effects. LQFM-091 has been proposed as a molecular hybridization from nimesulide and BF-389, with the aim to inhibit two enzymes involved in arachidonic acid metabolic cascade. The aim this work was the electrochemical characterization of LQFM-091. The electrochemical analyzes were conclusive to prove that the electroactive groups are unhindered and were important in this drug action mechanism. © 2018

Authors
De Siqueira Leite K.C. , Garcia L.F.1 , Sanz G.2 , Colmati F.2 , De Souza A.R. , Da Costa Batista D. , Menegatti R.1 , De Souza Gil E. , Luque R. 3, 4
Journal
Journal of Electroanalytical Chemistry
Language
English
Pages
92-96
Status
Published
Link
External link
DOI
10.1016/j.jelechem.2018.04.033
Volume
818
Year
2018
Organizations
  • 1 Faculdade de Farmácia, Universidade Federal de Goiás, Goiânia, GO 74605–220, Brazil
  • 2 Instituto de Química, Universidade Federal de Goiás, Goiânia, GO 74690-970, Brazil
  • 3 Departamento de Quimica Organica, Universidad de Cordoba, Campus de Rabanales, Edificio Marie Curie, Ctra Nnal IV-A, Km. 396, Cordoba, E14014, Spain
  • 4 Peoples Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya street, Moscow, 117198, Russian Federation
Keywords
Butylhydroxytoluene; Electroanalysis; Electrochemical characterization; Nimesulide; Novel drugs
Date of creation
19.10.2018
Date of change
19.10.2018
Short link
https://repository.rudn.ru/en/records/article/record/6627/
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