The study analyses the ratio of axiological orientation of Vietnamese students and their adaptability. The study demonstrates that the ratio of certain values, attitudes and needs form a specific type of axiological orientation. The study finds out that different types of orientation are interrelated with selective personality adaptive indicators of Vietnamese students and can be regarded as predictors of adaptation process. The study identifies current trends of adaptability studies within the context of system paradigm. The study points out the main determinants of personal adaptability manifestations. The methodological basis of the research was the dispositional concept of personality and individual traits investigation by A. Krupnov, as well as the provisions of the theory of personal potential by D. Leontiev, developed within the framework of positive psychology. The aim of the study presented in this article is to identify the relationship between the indicators of axiological orientation and adaptability variables in Vietnamese students. At the first stage of the study, different types of students' axiological orientation based on the results of cluster analysis have been identified and described: vocation and career, egocentric, sociability orientation types. Statistically significant differences between the selected types were recorded for most of the components. The meaningful characteristics of these types at the behavioural level, differ in attitude to training activities, relationship with other people and personal self-conception. In the next phase the features of adaptability among representatives with different types of axiological orientation were revealed. The correlation analysis was used to identify the correlation between axiological variables and adaptability. It turned out that all three groups are pressed by uncertainty, nostalgia and asthenic feelings. At the same time representatives of vocational and career axiological orientation type were more successful in adaptability, as compared to other groups. Students with egocentric orientation turned out less successful in adaptability. They are distinguished by the highest severity of negative background mood, uncertainty, difficulties in communication. As a conclusion, we defined the role of axiological orientation as the primary predictor of personal adaptability in multicultural environment.