Transformations of (γ-piperidono)dibenzoaza-14-crown-4 ethers

The transformations of dibenzo[(γ-piperidono]aza-14-crown-4 ethers were implemented with Li-organic compounds and sodium borohydride under reduction condition. The structures of new compounds were confirmed by1H NMR, IR, MS analysis. X-Ray single-crystal structure study has exactly determined the structure of the representative compound 2g. According to the PASS program, these obtained new azacrown ethers containing γ-piperidol fragment are interested to develop new biologically active agents such as a CYP2H substrate (60–95 %), membrane permeability inhibitor (60–74 %) and spasmolytic agent (60–92 %). © ISUCT Publishing.

Authors
Hieu T.H. 1, 5 , Komarova A.I. 2 , Levov A.N. 2 , Soldatenkov A.T. 2 , Polyakova E.I. 2 , Tuyen N.V. 1, 4 , Anh D.T.T.1, 4 , Kulakova A.N. 2 , Khrustalev V.N. 2 , Anh L.T. 3
Journal
Macroheterocycles
Number of issue
4
Language
English
Pages
409-414
Status
Published
Link
External link
DOI
10.6060/mhc190554a
Volume
12
Year
2019
Organizations
  • 1 Institute of Chemistry, Vietnam Academy of Science and Technology (VAST), Hanoi, Viet Nam
  • 2 Department of Inorganic Chemistry, Peoples’ Friendship, University of Russia, RUDN University), Moscow, 117198, Russian Federation
  • 3 Faculty of Chemistry, VNU University of Science, Vietnam National University, Hanoi, Viet Nam
  • 4 Graduate University of Science and Technology, VAST, Hanoi, Viet Nam
  • 5 Saigon Pharmaceutical Science-Technology Centre, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, 70000, Viet Nam
Keywords
Azacrown ether; Li-organic compound; Single-crystal X-ray structure; γ-piperidol
Date of creation
02.11.2020
Date of change
02.11.2020
Short link
https://repository.rudn.ru/en/records/article/record/65826/
Share

Other records

MEIOSIS, SPERMATOGENESIS AND ULTRASTRUCTURE OF THE BASEMENT MEMBRANE OF SEMINIFEROUS TUBULES IN PATIENTS WITH AZOOSPERMIA [МЕЙОЗ, СПЕРМАТОГЕНЕЗ И УЛЬТРАСТРУКТУРА БАЗАЛЬНОЙ МЕМБРАНЫ СЕМЕННЫХ КАНАЛЬЦЕВ У ПАЦИЕНТОВ С АЗООСПЕРМИЕЙ]

Article
Bragina E.E., Vityazeva I.I., Lelekova M.A., Kashintsova A.A., Bogolyubov S.V., Gabliya M.Yu., Vinogradov I.V., Spanberg V.E., Kolomiets O.L.
Андрология и генитальная хирургия. Некоммерческое партнерство "Профессиональная Ассоциация Андрологов". Vol. 20. 2019. P. 43-54

ON DOCTOR'S CRITICISM: AN INTERDISCIPLINARY APPROACH

Article
Kubryak O.V., Bagdasaryan N.G., Gerasimenko M.Y., Krasnov V.N., Kulyabina E.V., Podvoyskiy D.G., Trushchelev S.A.
Monitoring Obshchestvennogo Mneniya: Ekonomicheskie i Sotsial'nye Peremeny. Russian Public Opinion Research Center, VCIOM. Vol. 154. 2019. P. 295-313