Palladium (II)-catalysed intramolecular C–H functionalizations: Efficient synthesis of kealiinine C and analogues

An efficient palladium-catalysed C–H functionalization sequence has been developed for the synthesis of 2-aminoimidazole alkaloids (Kealiinine C) and its analogues. This protocol proceeds via iodocyclisation of propargylguanidines followed by intramolecular Pd-catalysed cyclisation. © 2018 Elsevier B.V.

Authors
Saha D.1, 3 , Stolarzewicz I.1 , Bahadur V.1, 2 , Sharma U.K.1 , Voskressensky L.G. 4 , Sharma A.3 , Singh B.K.2 , Van Der Eycken E.V.
Journal
Molecular Catalysis
Publisher
Elsevier B.V.
Language
English
Pages
233-238
Status
Published
Link
External link
DOI
10.1016/J.MCAT.2018.06.007
Volume
455
Year
2018
Organizations
  • 1 Laboratory for Organic & Microwave-Assisted Chemistry (LOMAC), Department of Chemistry, University of Leuven (KU Leuven), Celestijnenlaan 200F, Leuven, B-3001, Belgium
  • 2 Bioorganic Laboratory, Department of Chemistry, University of Delhi, Delhi, 110007, India
  • 3 Medicinal Chemistry Lab, Department of Chemistry, Indian Institute of Technology Roorkee, Uttarakhand, 247667, India
  • 4 Peoples Friendship University of Russia (RUDN University), Miklukho-Maklaya Street 6, Moscow, 117198, Russian Federation
Keywords
2-aminoimidazoles; C–H functionalization; Guanylation; Iodocyclization; Kealiinines
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