Mathematical Models and Computer Simulations.
Pleiades Publishing.
Vol. 12.
2020.
P. 293-301
The Effect of Surgical Trauma in the Nasal Cavity on the Behavior in the Open Field and the Autonomic Nervous System of Rats
Abstract: In this article, the effect of surgical damage to the nasal mucosa in rats under the action of general anesthesia was investigated. The motor activity and heart rate variability (HRV) of rats were studied before and 2 days after the surgery. After surgical exposure, motor activity decreased, the time of fading and grooming increased, VLF increased, and HF decreased. Surgical trauma of the nasal septum in rats at the early postoperative stage promotes a pronounced stress response in the form of a sharp shift in the balance of the autonomic nervous system towards the sympathetic level and causes a decrease in exploratory activity, an anxiety, and a depressive-like state in rats. © 2020, Pleiades Publishing, Ltd.
Authors
Kastyro I.V.
1
,
Reshetov I.V.2
,
Khamidulin G.V.
1
,
Shmaevsky P.E.
1
,
Karpukhina O.V.3
,
Inozemtsev A.N.
3
,
Torshin V.I.
1
,
Ermakova N.V.
1
,
Popadyuk V.I.
1
Number of issue
1
Language
English
Pages
121-123
Status
Published
Link
Volume
492
Year
2020
Organizations
- 1 Peoples’ Friendship University of Russia (RUDN University), Moscow, Russian Federation
- 2 Sechenov First Moscow State Medical University, Moscow, Russian Federation
- 3 Moscow State University, Moscow, Russian Federation
Keywords
grooming; heart rate variability; motor activity; septoplasty; stress
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