Facile Synthesis and Biological Evaluation of New Thieno[2,3-g]indolizine Derivatives

An effective approach to the synthesis of thieno[2,3-g]indolizine derivatives has been developed. A wide variety of reagents such as unsaturated aldehydes, methylvinylketone, esters of acrylic acid, maleic anhydride, methyl propiolate, dimethyl and diethyl acetylenedicarboxylates in the construction of functionally diverse rarely encountered tricyclic system has been used. A high number of structurally various thieno[2,3-g]indolizines has been obtained in domino reactions with medium and high yields, the influence of solvents on the course of transformations has been studied, and the presence of moderate cytotoxic activity for a number of compounds has been established. © 2020 Wiley-VCH GmbH

Authors
Zinoveva A.D. 1 , Borisova T.N. 1 , Politova P.A. 1 , Titov A.A. 1 , Varlamov A.V. 1 , Voskressensky L.G. 1 , Nguyen V.T. 2 , Le T.A. 3
Journal
ChemistrySelect
Publisher
Wiley-Blackwell
Number of issue
35
Language
English
Pages
10821-10826
Status
Published
Link
External link
DOI
10.1002/SLCT.202002684
Volume
5
Year
2020
Organizations
  • 1 Organic Chemistry Department, Peoples' Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya St, Moscow, 117198, Russian Federation
  • 2 Institute of Chemistry, Graduate University of Science and Technology, Vietnam Academy of Science and Technology, N. 18, Hoang Quoc Viet street, Can Giay, Hanoi, 100 000, Viet Nam
  • 3 Faculty of Chemistry, VNU University of Science, N. 19, Le Tong street, Hanoi, 100 000, Viet Nam
Keywords
alkaloids; domino reactions; thieno[2,3-g]indolizine; thieno[3,2-c]pyridine; zwitterions
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