Antidiabetic Biguanides as Anti-Aging Drugs

Evidence has emerged that metformin and other antidiabetic biguabides are promising candidates for pharmacological interventions leading to slowing down of aging, prolonged life span and preventing or postponing age-associate diseases, including cancer. In this chapter, the available data on effects of biguanides in rodents are summarized and discussed.

Authors
Anisimov V.N. 1, 2, 3
Journal
RSC Drug Discovery Series
Publisher
Royal Society of Chemistry
Number of issue
57
Language
English
Status
Published
Link
External link
DOI
10.1039/9781782626602-00416
Volume
2017-January
Year
2017
Organizations
  • 1 Department of Carcinogenesis and Oncogerontology, N.N. Petrov Research Institute of Oncology, Leningradskaya str., 68, Pesochny-2, St. Petersburg, 197758, Russian Federation
  • 2 Institute of Cytology, The Russian Academy of Sciences, Tikhoretsky prosp. 4, St.Petersburg, 194064, Russian Federation
  • 3 People Friendship University of Russia, Miklukho-Maklay str. 6, Moscow, 117198, Russian Federation
Keywords
buformin; carcinogen; metformin; phenformin; aging; amyotrophic lateral sclerosis; antiaging activity; Article; cancer inhibition; drug activity; Huntington chorea; lifespan; long term care; nonhuman; preclinical study
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