Purpose. To compare safety and feasibility of transradial approach (TRA) and trans-femoral approach (TFA) in patients undergoing bronchial artery embolization (BAE). Materials and methods. A total of 29 patients with massive or recurrent hemoptysis (15 in the TRA group and 14 in the TFA group) were included into the study. Clinical characteristics of the patients were comparable between the two groups. Patients were evaluated for the success and duration of the procedure, radiation exposure, complications, parameters of procedural discomfort. Results. The procedural success was 100% in both groups. The duration of BAE, radiation exposure, the rate of major and minor complications were comparable between the two groups. TRA was associated with a significant reduction in all parameters of procedural discomfort. Conclusion. TRA for BAE has the same efficacy and safety compared to TFA. The duration of the procedure and radiation exposure are comparable in both groups. Increased patient comfort after the procedure is the main advantage of TRA.