7-Dialkylaminomethyl-2,4,5-trimetyl- and 2,4,5-trimethyl-7-phenyliminomethyl-1,2,3,4-tetrahydropyrrolo[1,2-c]pyrimidines

The Mannich aminoalkylation of 2,4,5-trimethyl-1,2,3,4-tetrahydropyrrolo[1,2-c]pyrimidine and condensation of its 7-formyl derivative with aniline have been studied. 7-Morpholinomethyl- and 7-(N-methylpiperazinylmethyl)-substituted derivatives have been isolated. 7-Dimethylaminomethyl- and 7-phenyliminomethyl-substituted derivatives of tetrahydropyrrolo[1,2-c]pyrimidines are easily cleaved in the process of chromatographic isolation. ©1999 Kluwer Academic/Plenum Publishers.