Background. Recurrent vaginitides, lower urogenital tract diseases occurring at a frequency of 8-30%, are related to diagnostic and treatment difficulties. Case report. The paper describes a case of a complex diagnosis of recurrent vaginal biotope disorder in the presence of premature ovarian failure in a 40-year-old woman with a Mirena intrauterine device. The use of intravaginal agents and systemic antibiotics was short-term effective. Conclusion. After aerobic vaginitis, vulvovaginal candidiasis, and premature ovarian failure were diagnosed, the use of clindacin B prolong, ovipol clio led to the cessation of complaints and clinical manifestations of vaginal biotope disorders. © 2017, Bionika Media Ltd. All rights reserved.