The aim of the study was to assess the indices of blood and lymph microcirculation in the skin in healthy men under normal condition and in circulatory hypoxia. Thirty healthy men, aged 19 to 27, were examined. Evaluation of blood and lymph circulation was carried out by laser Doppler flowmetry (LDF) of the skin - the palmar surface of the base of thumb. The results showed that in occlusal period an increase in the lymph flow and decrease in blood flow were revealed, compared to normal conditions. In post-occlusal period a rapid recovery of blood circulation and slight decrease in lymph circulation were observed. Conclusion. Indices of blood and lymph circulation differ in normal conditions, in occlusal test and in post-occlusal period. Different reactivity of blood and lymph microvessels is observed in circulation recovery. The data obtained can be used for the diagnosis of blood and lymph flow disorders and assessment of local toxicosis severity under various pathological conditions.