Synthesis and cytotoxicity of novel γ-piperidone-containing dibenzo-1,7-diaza-14-crown-4 ethers

For the development of new antitumor agents, novel dibenzo-1,7-diaza-14-crown-4 ethers containing γ-piperidone moiety were synthesized by a domino condensation of new podands, ketones and ammonium acetate. The crystal structure of one Ts of them was studied by X-ray diffraction. Four crown compounds were evaluated in vitro for cytotoxic activity against 5 human cancer cell lines. © 2019

Authors
Le A.T. 1 , Tran V.T.T.1 , Truong H.H. 2 , Nguyen L.M.1, 3 , Luong D.M.1 , Do T.T.1 , Nguyen D.T. 1 , Dao N.T. 1 , Le D.T.1 , Soldatenkov A.T. 2 , Khrustalev V.N. 2, 4
Journal
Mendeleev Communications
Publisher
Royal Society of Chemistry
Number of issue
4
Language
English
Pages
375-377
Status
Published
Link
External link
DOI
10.1016/J.MENCOM.2019.07.004
Volume
29
Year
2019
Organizations
  • 1 Faculty of Chemistry, VNU University of Science, Hanoi, 100000, Viet Nam
  • 2 Department of Inorganic Chemistry, Peoples Friendship University of Russia (RUDN University), Moscow, 117198, Russian Federation
  • 3 Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Thai Nguyen University of Medicine and Pharmacy, Thai Nguyen City, Viet Nam
  • 4 National Research Center ‘Kurchatov Institute’, Moscow, 123182, Russian Federation
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