A simple synthesis of benzofurans by acid-catalyzed domino reaction of salicyl alcohols with N-tosylfurfurylamine

A simple route to polysubstituted benzofurans based on the domino reaction of commercial or easily available salicyl alcohols with N-protected furfurylamine has been designed and developed. The reaction was found to proceed with reasonable yields under heating of substrates in acetic acid in the presence of catalytic amount of conc. HCl when tosyl was used as protecting group. © 2017 Elsevier Ltd

Authors
Merkushev A.A.1, 2 , Strel'nikov V.N.2 , Uchuskin M.G. 1, 3 , Trushkov I.V. 3, 4
Journal
Tetrahedron
Number of issue
46
Language
English
Pages
6523-6529
Status
Published
Link
External link
DOI
10.1016/j.tet.2017.09.043
Volume
73
Year
2017
Organizations
  • 1 Perm State University, Bukireva 15, Perm, 614990, Russian Federation
  • 2 Institute of Technical Chemistry UB RAS, Academica Koroleva 3, Perm, 614013, Russian Federation
  • 3 RUDN University, Miklukho-Maklaya 6, Moscow, 117198, Russian Federation
  • 4 Dmitry Rogachev National Research Center of Pediatric Hematology, Oncology and Immunology, Samory Mashela 1, Moscow, 117997, Russian Federation
Keywords
Benzofurans; Bronsted acid catalysis; Domino reaction; Furan; Salicyl alcohols
Date of creation
19.10.2018
Date of change
28.09.2021
Short link
https://repository.rudn.ru/en/records/article/record/5179/
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