New possibilities of pharmacotherapy in cardiovascular patients with mental disorders

Objective. To study the efficacy and tolerability of the drugs pantogam active and phenotropil in mild neurotic, somatoform, stress-induced and depressive disorders developed in patients with cardiovascular diseases. Material and methods. The effect of pantogam active was assessed in an open study. The main group of patients (n=35) treated with phenotropil during 12 weeks was compared to the comparison group (n=35). Patient’s status was evaluated using psychometric (CGI, HDRS etc) and adverse effect scales. Results and conclusion. Statistically significant results demonstrated the advantages of pantogam active has advantage on a number of values. The treatment effect of pantogam active gradually increased while the effect (in particular anxiolytic one) of phenotropil decreased after 4—8 weeks of treatment. The tolerability of both drugs was satisfactory. © 2014, Media Sphera. All rights reserved.