Effect of Phosphocreatine and Ethylmethylhydroxypyridine Succinate on the Expression of Bax and Bcl-2 Proteins in Left-Ventricular Cardiomyocytes of Spontaneously Hypertensive Rats

We studied the effect of phosphocreatine and ethylmethylhydroxypyridine succinate on the expression of Bax and Bcl-2 proteins in left-ventricular cardiomyocytes of spontaneously hypertensive rats (SHR). Both drugs have no effect on the expression of Bcl-2, but significantly reduce the level of Bax protein (phosphocreatine produces more pronounced effect). These data attest to an important role of energy deficit and oxidative stress in the induction of cardiomyocyte apoptosis in genetically determined arterial hypertension. © 2015, Springer Science+Business Media New York.

Authors
Azova M.M. 1 , Blagonravov M.L. 1 , Frolov V.A. 1
Journal
Bulletin of Experimental Biology and Medicine
Publisher
New York Consultants BureauSpringer / Автономная некоммерческая организация Издательство Российской академии медицинских наук
Number of issue
3
Language
English
Pages
313-314
Status
Published
Link
External link
DOI
10.1007/s10517-015-2749-4
Volume
158
Year
2015
Organizations
  • 1 Department of General Pathology and Pathophysiology, People’s Friendship University of Russia, Moscow, Russian Federation
Keywords
apoptosis; cardiomyocyte; hypertension; mexidol; phosphocreatine
Date of creation
19.10.2018
Date of change
19.10.2018
Short link
https://repository.rudn.ru/en/records/article/record/4604/
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