Solubility of Diclofenac Acid Form from Solid Dispersions

The influence of solid dispersions (SD) on diclofenac solubility was determined by studying diclofenac (acid form) and its SD with polyethyleneglycol-1500 (PEG) and polyvinylpyrrolidone-10000 (PVP). SD formation increased the solubility and dissolution rate of the non-steroidal anti-inflammatory drug (NSAID). Diclofenac solubility from the SD with PVP increased by 2.5 times; from the SD with PEG (solvent evaporation method), by 8 times compared with diclofenac drug substance. A combination of physicochemical methods showed that the improved release of diclofenac from the SD occurred because of reduced crystallinity, formation of drug solid solutions in the polymer matrix, and formation of a colloidal drug solution. © 2015, Springer Science+Business Media New York.

Authors
Krasnyuk I.I.Jr. , Ovsyannikova L.V.1 , Nikulina O.I.1 , Belyatskaya A.V.1 , Krasnyuk I.I.1 , Kharitonov Y.Y.1 , Grikh V.V.1 , Korol’ L.A.1 , Obidchenko Y.A. 2 , Vorob’ev A.N. 2
Journal
Pharmaceutical Chemistry Journal
Number of issue
11
Language
English
Pages
733-737
Status
Published
Link
External link
DOI
10.1007/s11094-015-1183-2
Volume
48
Year
2015
Organizations
  • 1 Sechenov First Moscow State Medical University, Moscow, 119991, Russian Federation
  • 2 Research and Education Center of Collective Use, People’s Friendship University of Russia, Moscow, 117918, Russian Federation
Keywords
bioavailability; crystallinity; diclofenac; NSAID; polyethyleneglycol-1500; polyvinylpyrrolidone-10000; solid dispersions; solubility
Date of creation
19.10.2018
Date of change
19.10.2018
Short link
https://repository.rudn.ru/en/records/article/record/4595/
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