Transformations of 4-arylpyrrolo[1,2-a][1,4]benzodiazepines in three-component reactions with activated alkynes and CH, NH, SH, and OH acids

Three-component reactions of tetrahydropyrrolo[1,2-a][1,4]benzodiazepines with methyl propiolate or acetylacetylene and CH, NH, SH, and OH acids were studied in various solvents. The reaction direction is assumed to depend on the nucleophilicity of anion, formed through deprotonation of acid by the anionic center of initial Michael-type zwitterion. © 2015 Springer Science+Business Media New York.

Authors
Voskressensky L.G. 1 , Borisova T.N. 1 , Babakhanova M.I. 1 , Chervyakova T.M. 1 , Titov A.A. 1 , Novikov R.A.2 , Toze F. 3 , Dang T.T.A.4 , Varlamov A.V. 1
Journal
Chemistry of Heterocyclic Compounds
Publisher
Латвийский институт органического синтеза Латвийской академии наук / Springer New York Consultants Bureau
Number of issue
7
Language
English
Pages
639-646
Status
Published
Link
External link
DOI
10.1007/S10593-015-1751-0
Volume
51
Year
2015
Organizations
  • 1 People's Friendship University of Russia, 6 Miklukho-Maklaya St., Moscow, 117198, Russian Federation
  • 2 N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Ave., Moscow, 119991, Russian Federation
  • 3 University of Douala, P.O.Box 2415A, Douala, Cameroon
  • 4 Chemistry Institute, Vietnam Academy of Science and Technology, A18, Hoang Quoc Viet, Hanoi, Viet Nam
Keywords
Acetylacetylene; CH acids; Cleavage of pyrrolo[1,2-a][1,4]benzodiazepines.; Methyl propiolate; NH acids; OH acids; Pyrrolo[1,2-a][1,6]benzodiazonine; SH acids
Cite
ГОСТ MLA RIS BibTex
Share

Other records