The increased wireless network densification has resulted in availability of wireless access points (AP) in almost each and every indoor location (room, office, etc.). To provide complete in-building coverage very often an AP is deployed per room. In this paper we analyze signal-to-interference (SIR) ratio for wireless systems operating in neighboring rooms separated by walls of different materials by explicitly taking into account the propagation and wall penetration losses. Both AP and direct device-to-device (D2D) configurations are addressed. Our numerical results indicate that the performance of such system is characterized by both the loss exponent describing the propagation environment of interest and wall materials. We provide the numerical results for typical wall widths/materials and analyze them in detail. © ECMS Thorsten Claus, Frank Herrmann, Michael Manitz, Oliver Rose (Editors).