Arrhenius Kinetics As a Bioactivity Assessment Criterion for Drug Substances and Excipients

Arrhenius kinetic principles, in particular, Ea values, were used to assess the biological activity of drug substances in aqueous solutions with different D/H ratios. The obtained activation energies indicated that deuterium-depleted solutions had lower toxicity and biological activity. © 2016, Springer Science+Business Media New York.

Number of issue
11
Language
English
Pages
779-781
Status
Published
Volume
49
Year
2016
Organizations
  • 1 Russian University of People’s Friendship, 8 Miklukho-Maklaya St., Moscow, 117198, Russian Federation
Keywords
activation energy; drug substances; excipients
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