Different Kinds of Interferon-Corrective Therapy in Congenital and Acquired Interferonopathies

This paper reviews various Interferon (IFN) system disturbances - Interferonopathies. Interferonopathies classification developed by the author is suggested. In this paper author describes clinical specifics of Type I Interferonopathy associated with overexpression of interferon alfa - rare Mendelian genetic diseases, certain autoimmune diseases, immune dysregulation syndrome. Interferon-corrective therapy methods are described. The targeted type I interferonopathies therapy is aimed at blocking IFN alpha overexpression. Most common interferonopathies by IFN deficiency type: congenital or acquired IFN alpha/beta and IFN gamma deficiencys in children and adults, associated with abnormal viral or mycobacterial infection courses. Replacement IFN-therapy is indicated for patients with congenital IFN alpha therapy. In case of acquired IFN alpha deficiency the differentiated interferon-corrective therapy is performed. In both replacement and interferon-corrective therapies recombinant human IFN alpha 2b VIFERON (R) is used together with antioxidants, which is safe, has a good clinical efficiency and no side effects.