N-acylation and N-alkylation of bis(benzo)aza-14-crown-4 ethers. Novel hybrid compound - bis(furanyl)triazinethiolazacrown ether

Macroheterocycles containing aza-14-crown-4 ether subunit were synthesized by one-step domino reaction. They are interesting objects for study of physicochemical properties and types of transformation. The N-acylated and N-alkylated aza-14-crown-4 ethers were obtained in good yields. The new hybrid compound - bis(furanyl)triazinethiolazacrown ether - was formed by S-alkylation of N-chloroacyl derivative (3). According to the PASS program, these substances can be inhibitors of the permeability of cell membrane and act also as a CYP2H substrate. © ISUCT Publishing.

Authors
Hieu T.H. 1 , Komarova A.I. 2 , Levov A.N. 2 , Soldatenkov A.T. 2 , Polyakova E.I. 2 , Nguyen T.V.1, 4 , Anh D.T.T.1, 4 , Nguyen D.T.3 , Van T.T.T.3 , Anh L.T. 3
Journal
Macroheterocycles
Number of issue
4
Language
English
Pages
438-441
Status
Published
Link
External link
DOI
10.6060/MHC181002A
Volume
11
Year
2018
Organizations
  • 1 Institute of Chemistry, Vietnam Academy of Science and Technology, Hanoi, 100000, Viet Nam
  • 2 Department of Chemistry, Peoples’ Friendship University of Russia, Moscow, 117198, Russian Federation
  • 3 Faculty of Chemistry, VNU University of Science, Hanoi, 100000, Viet Nam
  • 4 Graduate University of Science and Technology, Vietnam Academy of Science and Technology, Hanoi, 100000, Viet Nam
Keywords
Acylation; Azacrown ether; Hybrid compound; Multicomponent condensation reaction; S-alkylation
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