The work presents the effectiveness of anthelmintic drugs in the treatment of canine intestinal nematodoses, since gastrointestinal parasites are the most common canine infectious agents and cause developmental delay, anorexia, anemia, diarrhea, which leads to significant damage to the dog's body and even death. In this regard, the analysis of the comparative efficacy of anthelmintic drugs for nematodoses in naturally invasive dogs was the aim of the present studies. As a result, it was found that using the combined therapeutic scheme of anthelmintic and probiotic, the complete disappearance of canine helminthiasis clinical signs was noted by the 10th day of treatment. This indicates a positive effect of symptomatic therapy for helminthiases. © 2018, Pharmainfo Publications. All rights reserved.