DYNAMICS OF OCCURRENCE AND REGRESSION OF NEUTROPHIL EXTRACELLULAR TRAPS IN THE EXPERIMENTAL MODEL OF THE WOUND INFECTIOUS-INFLAMMATORY PROCESS

The dynamics of the appearance and regression of neutrophilic extracellular traps (NETs) in the experimental model of the wound infectious-inflammatory process that was caused by infection of open wounds by microbes surrounding environment, was studied. It was established that on the second day from the start of the experiment a significant number of mature neutrophilic granulocytes show the ability to form NEТs. The number of NETs was reached its maximum by the 2th and 4th days from the beginning of the experiment, that was associated with maximum occurrence of symptoms of inflammation in the wound. The regression of the wound inflammatory process was associated with decreasing of the number of NETs to 7th day and the complete disappearance of NETs to 14th day of the experiment, which coincided with the healing of wounds.