SNP-detecting DNA technologies: Solving problems of applied biochemistry

The heterozygosity of CANP3, ACTN3, and GHR genes in specialized collections was studied using state-of-the-art DNA technologies for DNA analysis. A new dinucleotide deletion (AC) at the beginning of exon 21 was identified in five individuals with a heterozygous CANP3 gene. Analysis of polymorphism (1747 C → T) of the ACTN3 gene demonstrated a positive association of allele C with high muscular performance. Real-time PCR assay of SNP1630 (A → C) in the GHR gene suggested a putative negative association of allele C of this SNP with high muscular performance. © 2005 MAIK "Nauka/Interperiodica".

Authors
Krakhmaleva I.N.1 , Shishkin S.S.1 , Shakhovskaya N.I.2 , Stolyarova E.B.1 , Plugov A.G. 3 , Knyazev A.I.1 , Khomenkov V.G.1 , Shevelev A.B.1 , Chernov N.N. 3
Journal
Applied Biochemistry and Microbiology
Number of issue
3
Language
English
Pages
264-268
Status
Published
Link
External link
DOI
10.1007/S10438-005-0045-1
Volume
41
Year
2005
Organizations
  • 1 Bach Institute of Biochemistry, Russian Academy of Sciences, Moscow, 119071, Russian Federation
  • 2 Moscow Regional Psychoneurological Hospital, Moscow, 127486, Russian Federation
  • 3 People's Friendship University of Russia, Moscow, 117198, Russian Federation
Keywords
genomic DNA; ACTN3 gene; allele; article; biochemistry; CANP3 gene; controlled study; DNA determination; exon; gene; gene deletion; GHR gene; heterozygosity; human; muscle function; reverse transcription polymerase chain reaction; single nucleotide polymorphism
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