Experimental model of hemorrhagic stroke: Rabbit immunization with HL-60 promyelocytic cell differentiation factor

Rabbits immunized with synthetic HLDF differentiation factor developed hemorrhagic stroke with thrombosis of small cerebral vessels and destruction of vascular endotheliocytes. The severity of stroke correlated with serum level of antibodies to differentiation factor. The role of different sites of HLDF molecule in the induction of clinical signs of hemorrhagic stroke was studied. © Springer Science+Business Media, Inc. 2006.

Authors
Gapon M.V.1 , Dranitsyna S.M.1 , Minkevich N.I.1 , Gruden' M.A.2 , Babichenko I.I. 3 , Kostanyan I.A.1
Journal
Bulletin of Experimental Biology and Medicine
Publisher
New York Consultants BureauSpringer / Автономная некоммерческая организация Издательство Российской академии медицинских наук
Number of issue
2
Language
English
Pages
272-274
Status
Published
Link
External link
DOI
10.1007/S10517-006-0147-7
Volume
141
Year
2006
Organizations
  • 1 Laboratory of Hormonal Regulation Proteins, M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Organic Biochemistry, Russian Academy of Sciences, Moscow, Russian Federation
  • 2 Laboratory of Neurochemistry, P. K. Anokhin Institute of Normal Physiology, Russian Academy of Medical Sciences, Moscow, Russian Federation
  • 3 Department of Pathological Anatomy, Medical Faculty of Russian University of Peoples' Friendship, Russian Federation
Keywords
Experimental model of hemorrhagic stroke; HLDF; Immunization
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