In vivo anticancer activity of lysates from Trypanosoma cruzi of different genetic groups

Lyzed epimastigotes of Trypanosoma cruzi clones P209-1, Gamba1, Sp104-1, MASu, Y7/1, MN12, Cl-Brener, 86/2036, Y7/2-1 inhibit the growth of Ehrlich adenocarcinoma in mice. The tumor decreased 1.5-3 times after 12 daily injections of lysates from 15 million epimastigotes. The protective effect progressed after the injections were discontinued and depended on the dose and lysate producer clone. Trypanosoma lysates in the studied doses were nontoxic. © Springer Science+Business Media, Inc. 2006.

Authors
Batmonkh Z.1 , Kallinikova V.D. 2 , Pakhorukova L.V. 2 , Kravtsov E.G. 1 , Karpenko L.P. 1 , Dalin M.V. 1
Journal
Bulletin of Experimental Biology and Medicine
Publisher
New York Consultants BureauSpringer / Автономная некоммерческая организация Издательство Российской академии медицинских наук
Number of issue
4
Language
English
Pages
470-473
Status
Published
Link
External link
DOI
10.1007/s10517-006-0395-6
Volume
142
Year
2006
Organizations
  • 1 M. V. Lomonosov Moscow State University, Russian Federation
  • 2 Russian University of Peoples' Friendship, Moscow, Russian Federation
Keywords
Antitumoractivity; Clone; Lysate; Trypanosoma cruzi
Date of creation
19.10.2018
Date of change
19.10.2018
Short link
https://repository.rudn.ru/en/records/article/record/3335/
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