Chemistry of Heterocyclic Compounds.
Латвийский институт органического синтеза Латвийской академии наук / Springer New York Consultants Bureau.
Vol. 43.
2007.
P. 1420-1425
Reduction of alcohol dependence in rats after carotid glomectomy
Carotid glomectomy significantly reduced the degree of alcohol addiction in rats, which was induced over 12 weeks. After glomectomy, the mean weekly volume of alcohol consumed by alcoholic animals over 4 weeks was lower compared to the preoperation level, while water consumption significantly increased by the 3rd and 4th weeks after surgery. Control sham operation had no effect on ethanol and water consumption in alcoholic rats. Possible involvement of the local renin-angiotensin system in chemoreceptor cells of the carotid body into systemic mechanisms of alcohol dependence is discussed. © Springer Science+Business Media, Inc. 2007.
Authors
Publisher
New York Consultants BureauSpringer / Автономная некоммерческая организация Издательство Российской академии медицинских наук
Number of issue
5
Language
English
Pages
650-652
Status
Published
Link
Volume
144
Year
2007
Organizations
- 1 Laboratory for Physiology of Motivations, P. K. Anokhin Institute of Normal Physiology, Russian Academy of Medical Sciences, Russian Federation
- 2 Department of Normal Physiology, Medical Faculty, People's Friendship University of Russia, Moscow, Russian Federation
Keywords
Alcohol dependence; Carotid body; Ethanol; Renin-angiotensin system
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Human Physiology.
Vol. 33.
2007.
P. 715-719