Acta Crystallographica Section E: Structure Reports Online.
Vol. 68.
2012.
P. o2848-o2849
Expression of peroxiredoxin 1, 2, 3, and 6 genes in cancer cells during drug resistance formation
We studied the expression of peroxiredoxin genes (PRDX1, PRDX2, PRDX3, and PRDX6) in human erythroleukemia K652, human breast carcinoma MCF-7, and human ovarian carcinoma SKOV-3 cells during cisplatin resistance development. It was found that drug resistance formation was accompanied by a significant increase in the expression of PRDX1, PRDX2, PRDX3, PRDX6 genes in all cancer cell strains, which confirms the important contribution of redox-dependent mechanisms into the development of cisplatin resistance of cancer cells. © 2012 Springer Science+Business Media New York.
Authors
Kalinina E.V.
1
,
Berezov T.T.
1
,
Shtil A.A.2
,
Chernov N.N.
1
,
Glazunova V.A.2
,
Novichkova M.D.
1
,
Nurmuradov N.K.
1
Publisher
New York Consultants BureauSpringer / Автономная некоммерческая организация Издательство Российской академии медицинских наук
Number of issue
6
Language
English
Pages
879-882
Status
Published
Link
Volume
153
Year
2012
Organizations
- 1 Peoples’ Friendship University of Russia
- 2 N. N. Blokhin Cancer Research Center, Russian Academy of Medical Sciences, Moscow, Russian Federation
Keywords
Cisplatin; Drug resistance of tumor cells; Gene expression; Peroxiredoxin
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Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics).
Vol. 7469 LNCS.
2012.
P. 440-452