The use of nano particles in engineering have become increasingly popular recently. This has brought rise to the study of nano admixtures like—nano-silica (NS), nano-alumina (NA), nano-clay (NC), nano-titania (NT), carbon nanotubes (CNTs), and graphene oxide (GO)—on the physicochemical and microstructural properties and how they can be applied in hybrid fiber-reinforced concrete (HyFRC) for use in aerodrome pavements. The research was prompted by the need to enhance the strength, durability, and sustainability of pavements exposed to heavy loads and harsh environmental conditions. A comprehensive literature review and data synthesis methodology was employed, analyzing various studies that tested nano-admixtures at specific dosages. Mechanical tests measured compressive and flexural strength, while durability assessments focused on water absorption and porosity. Results revealed that NS, NA, and NT significantly improved strength and matrix densification. CNTs and GO produced the highest gains—up to 60% in compressive strength and 46% reduction in water absorption. While NC offered some porosity improvements, its overall performance was limited. GO emerged as the most effective additive, delivering superior strength and durability enhancements even at low dosages. The study concludes that nano-admixtures—particularly GO, CNTs, NA, and NS—hold strong potential for optimizing HyFRC in aerodrome applications. It recommends further research into combined admixture effects and long-term field validation to support practical implementation.