Effects of aminophylline, bendazol, bencyclane and drotaverine on osmotic resistance of thrombocytes and on clot retraction (Russian)

The osmotic resistance of thrombocytes and the blood clot retraction are shown to diminish in the presence of bencyclane and drotaverine in the plasma and blood. A double logarithmic relationship between the values characterizing the action on the osmotic resistance of thrombocytes and the blood clot retraction, on the one hand, and concentrations of some of the study substances, on the other, was revealed. With parenteral introduction the fall of the osmotic resistance of thrombocytes and an increase in the amount of the retracted serum were noted to occur with a protracted subcutaneous injection of bendazol (5 mg/kg), whereas aminophylline (24 mg/kg) caused only a smaller degree of retraction.

Authors
Kremneva V.F. 1 , Zagorskaya I.B.1
Journal
Farmakologiya i Toksikologiya
Number of issue
3
Language
Russian
Pages
324-327
Status
Published
Link
External link
Volume
38
Year
1975
Organizations
  • 1 Kaf. Farmakol., Univ. Druzhby Narodov, Moscow
Keywords
aminophylline; bencyclane; bencyclane fumarate; bendazol; dibazol; drotaverine; unclassified drug; aminophylline; antihypertensive agent; bencyclane; benzimidazole derivative; benzyl derivative; drug derivative; ether derivative; isoquinoline derivative; papaverine; vasodilator agent; blood clot retraction; blood clotting; blood clotting test; in vitro study; internal medicine; osmoregulation; osmotic resistance; subcutaneous drug administration; theoretical study; thrombocyte; animal; article; comparative study; dose response; drug effect; female; male; mathematics; osmotic fragility; pharmaceutics; rat; thrombocyte; time; Aminophylline; Animal; Antihypertensive Agents; Bencyclane; Benzimidazoles; Benzyl Compounds; Biopharmaceutics; Blood Platelets; Clot Retraction; Comparative Study; Dose-Response Relationship, Drug; English Abstract; Ethers; Female; In Vitro; Isoquinolines; Male; Mathematics; Osmotic Fragility; Papaverine; Rats; Time Factors; Vasodilator Agents
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