INTRODUCTION. Soft tissue plastic surgery is usually accompanied by the harvesting of a gingival graft from the hard palate. The exposed donor wound surface may cause pain and the possibility of wound infection cannot be ruled out. Medical adhesives have recently been increasingly used as wound coverings on the donor area. AIM. Comparison of antibacterial activity of medical adhesives from different manufacturers. MATERIALS AND METHODS. The tests used medical adhesives Sulfacrylate (NTO MedIn), Histoacryl (B. Braun), Hemocompact (MTPO Inter-Vita). Chlorhexidine (0.05% solution) was used as a control antiseptic. The antimicrobial activity of various adhesives was tested on Staphylococcus aureus and isolates of Streptococcus salivarius, Streptococcus sobrinus and Candida albicans. RESULTS. All the presented preparations have antibacterial activity, but it is most pronounced in the domestic manufacturer’s glue based on ethyl cyanoacrylic acid. CONCLUSIONS. The antibacterial activity declared by the manufacturer of medical adhesives against opportunistic strains of microorganisms that are permanent inhabitants of the oral cavity was experimentally confirmed. © Bakaev Yu.A., Khabadze Z.S., Magomedov O.I., Kudzheva A.T., Kakabadze E.M., Umarov A.Y., Wehbe A., 2025.