Post-hysterectomy vaginal vault prolapse (PHVVP) remains a topical problem in pelvic floor reconstructive surgery. Objective: To compare the effectiveness of two different surgical approaches for the treatment of PHVVP in postmenopausal women: laparoscopic lateral vaginal vault fixation with mesh implant and vaginal colpocleisis (median colporrhaphy) using autologous tissues. Materials and methods: 61 patients with PHVVP were examined in the Department of Operative Gynecology of the Bauman City Hospital No. 29 during the period of December 2022–December 2025. In group P (n=39), laparoscopic lateral fixation of the vaginal vault with a mesh implant was performed. In group B (n=22), midline colporrhaphy was conducted using the patient's own tissues. Anatomical results were assessed using the POP-Q system. The subjective results were evaluated using the PFDI-20 and PFIQ-7 questionnaires. Results: After finishing of the surgeries in both groups, we were continuing observations, repeated examinations of the patients and questionnaire surveys for 3 years. The overall objective effectiveness rate in Group P was 84.6% (33/39), in Group B – 90.9% (20/22). According to the results of the PFDI-20 and PFIQ-7 questionnaires, the level of subjective effectiveness of the surgery in Group P was 92.3% (36/39), in Group B – 86.3% (19/22). Conclusion: Both laparoscopic lateral fixation of the vaginal vault with a mesh implant and median colporrhaphy in PHVVP give opportunity to achieve good anatomical results with minimal complications. However, the higher recurrence rate of apical prolapse after vaginal surgery using the patient's own tissues doubts the effectiveness of midline colporrhaphy in patients with PHVVP. © A group of authors, 2025.