Cardiovascular disease (CVD) is one of the leading causes of mortality worldwide, making it an important factor when planning dental treatment. Patients with CVD require a special approach in dental practice, as their health status can significantly influence the choice of treatment meth-ods, anaesthesia and postoperative care. This article discusses the need to develop an individualised dental treatment plan for these patients in order to minimise risks and preserve their overall health. The focus is on the relationship between dental disease and the cardiovascular system. For example, chronic oral inflammation, such as periodontitis, can exacerbate the course of cardiovascular disease by increasing the risk of heart attacks and strokes. At the same time, certain dental procedures, such as tooth extraction or implantation, can cause a stress response in the body, which is particularly dangerous for patients with CVD. The authors of the article emphasise the importance of a multidisciplinary approach, including consultation with cardiologists, to develop a safe and effective treatment plan. Particular attention is paid to the choice of anaesthesia: the use of drugs with minimal impact on the cardiovascular system is recommended. Prevention of infectious complications, which can be particularly dangerous for patients with CHD, is also discussed. The article provides recommendations for adapting dental treatment for patients with various forms of cardiovascular pathology, including hypertension, ischaemic heart disease and heart failure. The need for careful history taking, risk assessment and ongoing monitoring of the patient during and after treatment is emphasised. The emphasis is made on the fact that an individual approach to dental treatment of patients with CVD not only improves their quality of life, but also helps to reduce the risk of complications from the cardiovascular system. © 2025, Venezuelan Society of Pharmacology and Clinical and Therapeutic Pharmacology. All rights reserved.