Опыт применения морской воды с ионами серебра в элиминационной терапии полипозного синусита

Seawater with silver ions in the elimination therapy of polypous sinusitis

Introduction. The main mechanism of the pathological process in polypous rhinosinusitis involves mucous membrane remodelling due to alterations followed by the formation of polypous vegetations that are likely to relapse. Aim. To conduct a clinical evaluation of the efficacy of the use of seawater spray with silver ions as part of the elimination therapy of polypous sinusitis. Materials and methods. We conducted a prospective randomized clinical trial involving 66 patients aged 20 to 46 years on an outpatient basis. The inclusion criterion included a diagnosis of chronic polypous rhinosinusitis in the exacerbation phase with attachment of a bacterial infection. All patients were randomly divided into 2 groups. The efficacy and safety of the use of seawater spray with silver ions was assessed on Days 3, 5 and 7 of treatment in Group 1 (n = 32) as compared to Group 2 (n = 34) which used the standard seawater spay. Results and discussion. On Day 7, the nasal breathing improved in 96.5% of patients in Group 1 and in 45% of patients in Group 2. 97.5% of patients in Group 1 reported the absence of nasal discharge on Day 7 as compare with 56.5% of patients in Group 2. The absence of postnasal drip was noted on Day 7 of therapy in 98.5% of patients in Group 1 and in 2.5% of patients in Group 2, respectively. The SF-36 QoL trend scores showed a more significant improvement of the patients’ health status on Day 7 of the therapy from 89.4 to 98.9 scores and from 84.6 to 91.1 points in patients of Groups 1 and 2, respectively. Conclusions. The clinical assessment of the efficacy of the use of seawater spray with silver ions as part of the elimination therapy of polypous sinusitis discovered a significant reduction in clinical symptoms. © Попадюк ВИ, Карпов ИА, Ленгина МА, Коркмазов АМ, Корнова НВ, 2025