Pain is a complex, distressing sensory and emotional experience directly associated with actual or potential tissue damage. Short-term pain serves a protective signaling function; however, under prolonged action of pathogenic factors and dysfunction of the nociceptive system, acute pain responses can transform into a pathological state. This state is characterized by a persistent pain syndrome lasting beyond normal healing time (usually more than 3–6 months), leading to the development of Chronic Pain Syndrome (CPS) and Chronic Post-Traumatic Pain (CPTP). These phenomena entail complex negative consequences: persistent physiological shifts, significant functional limitations, neurological disorders, and various mental disorders. Chronic Pain Syndrome has a profoundly negative impact on all aspects of patients’ quality of life. A critically important aspect is its ability to significantly hinder the rehabilitation process. The present article details the clinical phenomena of CPS and CPTP, analyzes their specific impact on the psychoemotional status and, consequently, on patients’ rehabilitation potential. Scientific data is presented demonstrating how various negative factors of the pain syndrome directly impede the implementation of therapeutic measures, reduce treatment adherence, and diminish the effectiveness of rehabilitation programs in patients who have suffered various injuries. The article also describes the influence of attachment style on patients’ individual experience of pain and introduces the hypothesis that rehabilitation of such patients might be possible using psychological techniques aimed at strengthening self-identity of self. The article emphasizes the necessity of a comprehensive treatment approach integrating pain management and psychological intervention. © 2026, Remedium Group Ltd. All rights reserved.