New insights in the pathogenesis of endometriosis: the role of stem cells

This review analyzes the hypothesis of the role of stem cells in the pathogenesis of endometriosis. The source of these cells can be both the uterine endometrium itself and the red bone marrow. Stem cells forming ectopic foci must have several features: the ability to migrate, attach and potentiate angiogenesis at the site of implantation, as well as differentiate into both glandular and stromal cells. Despite numerous studies, the cells responsible for the development of endo metrioid lesions have not yet been identified. If an ectopic endometrial progenitor cell is found, it will be possible to use its features to predict the course of disease and the efficacy of therapy. © Издательство «Династия», 2024.