Angiogenesis in the autologous adipose tissue graft after various methods of preoperative fat treatment in rats

The article presents studies of angiogenesis in the autologous adipose tissue graft after various methods of its preoperative processing (solid graft, fragmenting with a scalpel, fat homogenized using a Luer Lock syringe) in rats at 30, 90 and 180 days after lipofilling simulation. We found that the number of microcirculatory vessels (MCVs) in the recipient site after 30 days was significantly lower in the fragmented fat group (p<0.05) compared with the solid graft group (p<0.05). After 90 days, the lowest proportion of MCVs was in the homogenized fat group (p<0.01). At 180 days after simulated lipofilling, the highest number of MCVs was observed in the homogenized fat group compared with the fragmented fat group (p<0.001). In all groups, the proportion of MCVs decreased significantly from day 30 to day 180. The best vascularization of adipose tissue at 180 days after lipofilling simulation in rats was observed with the transplantation of homogenized fat. © 2024, All-Russian Federation of the Specialists in Head and Neck Diseases. All rights reserved.

Authors
Khlystalov M.V. , Moroz S.E. , Kastyro I.V. , Lavrentieva E.A. , Ibadullaeva S.S. , Ganshin I.B. , Shalamov K.P. , Popadyuk V.I. , Kostyaeva M.G. , Kartasheva A.F. , Barannik M.I. , Sarygin P.V.
Journal
Голова и шея. Российское издание. Журнал Общероссийской общественной организации "Федерация специалистов по лечению заболеваний головы и шеи"
Number of issue
3
Language
Russian
Pages
57-62
Status
Published
Link
External link
DOI
10.25792/HN.2024.12.3.57-62
Volume
12
Year
2024
Organizations
  • 1 Department of Plastic Surgery, Peoples' Friendship University of Russia, 8 Miklukho-Maklaya str., Moscow, 117198, Russian Federation
  • 2 Department of Clinical Physiology and Non-Drug Therapy Methods, Peoples' Friendship University of Russia, 8 Miklukho-Maklaya str., Moscow, 117198, Russian Federation
  • 3 Department of Otorhinolaryngology, Peoples' Friendship University of Russia, Moscow, Russian Federation
  • 4 Department of Histology, Cytology and Embryology, Peoples' Friendship University of Russia, Moscow, Russian Federation
  • 5 Peoples' Friendship University of Russia, 8 Miklukho-Maklaya str., Moscow, 117198, Russian Federation
Keywords
fat graft; lipofilling; microvasculature; neoangiogenesis
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